• Le 13 mars 2020
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  • ** Séminaire annulé **

"Unprecedented roles of RNA interference factors during early development"

Dr Constance Ciaudo

"Despite sharing the same genome, different cell types in a given organism respond in unique fashions to environmental, developmental and metabolic cues. Underlying this plasticity is a complex network of gene regulation, which is instrumental to ensure the establishment and maintenance of cellular identity during the entire organismal life time. The mechanistic underpinnings of such regulation are incompletely understood.

RNA interference (RNAi) proteins have emerged as critical guardians of eukaryotic genome integrity by mediating gene silencing through the use of small RNAs (sRNAs) and by controlling transposable elements (TEs). In addition to their well-described roles in the biogenesis of microRNAs (miRNAs), it has recently become evident that RNAi effector proteins have other noncanonical, yet essential, functions in mammalian cell development and homeostasis. Moreover, the genes coding for these effector proteins are often mutated in diseases, including cancer. It is therefore of chief interest to clarify canonical as well as noncanonical contributions of RNAi proteins to the orchestration of gene expression and TE control in cellular development and disease

Our goal is to characterize the diverse functions of individual RNAi proteins and translate this obtained knowledge to a disease context. This will offer important insights in developmental and genome biology, stem cell research and regenerative medicine."