• Le 07 janvier 2020
    Campus Centre Loire

" Régulation des réponses immunes par l’heme oxygenase-1 d’origine myéloïde "

Alain LE MOINE is the head of the nephrology dialysis and transplantation department at Erasme Hospital, Université libre de Bruxelles. After a trainee in nephrology at Erasme hospital and Necker hospital (Pr J.P Grünfeld), he was PhD student for four years dealing with new T cell pathways of allograft rejection (co-supervisors : Pr M Goldman and Pr D Abramowicz). Next, he joined the laboratory of H. Waldmann in Oxford University for a postdoctoral stay abroad, working on allograft tolerance and regulatory T cells. Coming back to Brussels in 2003, he obtained a research associate position at the National Fund for Scientific Research (FNRS) working on regulatory T cells and in European tolerance networks. He was responsible of a small research group at the Institute for Medical Immunology (Pr M. Goldman) developing several experimental models of immunomodulation and tolerance induction in the context of transplantation and acute kidney injury. Several questions have been raised including regulatory T cells, co-stimulation blockade, mixed donor/recipient chimerism, TLR desensitization, the cholinergic anti-inflammatory pathway and myeloid-derived suppressor cells. In the latter, we observed an important role for the heme oxygenase-1 (HO-1) in immune regulation mechanisms, including human data. To take benefit from inhibiting or inducing HO-1 depending on the circumstances are now tested in appropriated immune experimental models. We recently developed collaborations with Pr. Marchant and the HLA laboratory at Erasme hospital for investigating glycosylation profiles of anti-HLA alloantibodies in sensitized transplant recipients.

Development of new approaches for the fabrication of polymeric scaffolds for Tissue Engineering applications.

Furthermore, he was a researcher at the department of Neurosciences, University of Pisa, where he developed scaffolds for otology surgery applications. Currently, his main research interests are focused on biofabrication, bioprinting and additive manufacturing techniques for the development of tissue engineered constructs.

Invité par le Dr Sophie Brouard