• Le 01 décembre 2020
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  • 11h via zoom

« HLA alloantibodies are inequal in their ability to modulate endothelial cell expansion of FoxP3high T-regulatory cells »

Dr Nuala MOONEY, ​INSERM UMR-S 976, Human Immunology, Pathophysiology & Immunotherapy, 
Institut de Recherche Saint Louis Centre Hayem - Hôpital Saint-Louis

Abstract : My team is part of the INSERM Unité 976 « Human Immunology, Physiopathology and Immunotherapies », co-directed by Armand Bensussan and Vassili Soumelis at the Hôpital Saint Louis, Paris. From a background in antigen presentation, I became interested in the immunobiology of HLA class II molecules and their function in signal transduction and the outcome of such signaling, mainly in B lymphocytes and Dendritic cells. This led to studying the expression of HLA molecules by endothelial cells which are atypical antigen presenting cells, and particularly in the context of transplantation. While HLA molecules are expressed by the renal microvascular endothelium in the steady-state, the level is greatly increased in response to inflammation induced by transplantation. Over the last years, we have demonstrated new roles for HLA class II antigens expressed by microvascular endothelial cells and how immunosuppressors, inflammation and interaction with Donor-Specific-Antibodies can modify their function. We are currently pursuing studies to better understand mechanisms of recruitment of the allograft inflammatory infiltrate induced by HLA class II/DSA interactions and associated with chronic rejection.

Invitée par le Dr Sophie Brouard