Organoids Nantes

A unique and privileged access to all the "organoid" expertise of the laboratories and platforms of the Nantes site

Organoids are cell models that are intermediate between monolayer cell cultures and in vivo models. They are developed thanks to advances in recent decades in stem cell culture and differentiation, as well as 3D culture. These three-dimensional models have the advantage of being produced from cells of the same species, unlike animal models. Using them makes it possible to get closer to physiological and/or pathophysiological conditions in order to increase the knowledge of tissue functioning, in the presence or absence of external molecules.

These fast-growing technologies meet the requirement to reduce animal models according to the 3R principle (FC3R)

infrastructure-organoides@univ-nantes.fr

Maxime Mahé, scientific manager – researcher UMR1235 TENS
Laurent David, deputy scientific officer – iPSCDTC platform scientific manager

Skills

The ION research infrastructure offers organoid models to the scientific community and health companies. To do this, ION brings together the expertise of Nantes laboratories around the use and study of several types of organoids (e.g. organ avatars) representing all the organs and diseases studied presented in the diagram below.

ORGANOIDS PRODUCTION

The players in the Nantes area have pooled their expertise to offer you an integrated multi-organ study offer.

Organs for which at least one team from Nantes has developed an organoid or spheroid or tumoroid

ORGANOIDS ANALYSIS

The teams at the Nantes platforms are also able to characterize the generated 3D structures.

                                                   Imaging                           Transcriptomic                            Cytometry                   Biomechanics                 Cellular models
                              
                                     MicroPICell platform                GenoA platform                            Cytocell platform            Bio3 platform               Therassay platform

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         HIO/Intestin ©Maxime Mahé                     Blastocyste ©Laurent David   MCTS/mésothélium ©Christophe Blanquart     Rhéomètre ©PF Bio3

• All the actors in the “Pays de la Loire” and in “Bretagne” developing or studying organoids are listed on a map available on the OuestOïd page (projet fédérateur Biogenouest)
• Learn more about organoids - Demystification: Understanding Organoids and Their Applications (in french)
• The TENS laboratory popularized its work on intestinal organoids during an O'tablo session.

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