ViVeM Center

Formely know as "CPV core facility", ViVeM center offers an integrated service for the development of a "drug candidate" viral vector from proof of concept to the production of characterized pre-clinical batches for regulatory toxicology studies. Usually our production service can provide viral vectors derived from adenovirus-associated viruses (AAV) serotypes 1 to rh10, novel variants and research-grade adenovirus.

An R&D team develops innovative compliant-GMP (Good Manufacturing Practice) production and purification processes, including a quality control team that develops specific analytical methods for the vectors produced. The developed processes are directly transfered within a pharmaceutical establishment for the production and characterization of clinical grade vector batches.

The pre-clinical platform also provides technical, scientific and regulatory advices for users.

Photo Credit : University of Nantes

Types of services

To implement these activities, the platform relies on specific know-how :
  • developing tools and processes for the production, purification and characterization of clinical grade viral vectors
  • produce pre-clinical grade viral vectors (research grade)
  • advising on the choice of vectors (viral vector design) and their use

Examples of achievements

The vectors produced within the platform find solid applications in several fields:
  • medicine and human health
  • gene therapy
  • medical research
  • clinical research and trials
  • biology and biotechnologies
  • genetic engineering
  • cell and molecular biology


  • For cell culture and quality control :
    • 15 Biosafety cabinet-class II
    • 21 CO2 incubators
    • 7 freezers -80°C
    • 3 ultracentrifuges
    • 1 quantitative PCR
    • 1 DNA extraction robot Starlet Hamilton
    • Spectrophotometer, fluorometer, luminometer
    • 1 VICELL cell counting system
    • 1 fluorescence microscope
  • Equipment specific to the activity :
    • 3 Biostat bioreactors
    • BSL3 and double input autoclave
    • 5 liquid chromatography chains including 1 Akta Ready
    • 2 TFF KR2i systems
Mis à jour le 29 March 2024.